NCLEX isolation precautions: contact, droplet and airborne
Standard precautions apply to every client. Add contact precautions (gown and gloves) for MRSA, VRE, C. diff, scabies and RSV; droplet precautions (a surgical mask on entering the room) for influenza, pertussis, meningococcal disease, mumps and rubella; and airborne precautions (a fit-tested N95 and a negative-pressure airborne infection isolation room) for tuberculosis, measles, chickenpox and disseminated zoster. CDC's order for putting PPE on is gown, mask or respirator, goggles or face shield, gloves; taking it off starts with the gloves and ends with the mask. The details below are the ones the distractors are built from.
Which precaution for which disease
| Precaution | Classic NCLEX diseases | PPE | Room |
|---|---|---|---|
| Standard (every client) | Everyone, including HIV and hepatitis B and C | Hand hygiene; gloves for blood and body fluids; gown, mask and eye protection if splashes are likely; no recapping needles | No special room |
| Contact | MRSA, VRE and other multidrug-resistant organisms; RSV; scabies; rotavirus and norovirus; major draining wounds | Gown and gloves for any contact with the client or the room; dedicated BP cuff and stethoscope | Private room, or cohort with the same organism |
| Contact, C. diff | Clostridioides difficile | Gown and gloves; soap-and-water hand washing, because alcohol does not kill spores | Private room; sporicidal (bleach-type) cleaning |
| Droplet | Influenza, pertussis, meningococcal meningitis, mumps, rubella, pharyngeal diphtheria | Surgical mask, put on when entering the room | Private room, or cohort with the same pathogen |
| Airborne | Pulmonary or laryngeal TB (confirmed or suspected), measles | Fit-tested N95 or higher respirator, on before entering | Airborne infection isolation room (AIIR): negative pressure, door closed |
| Airborne + contact | Chickenpox, disseminated zoster, and localized zoster in an immunocompromised client until dissemination is ruled out | N95 plus gown and gloves | AIIR |
COVID-19 does not fit one row. CDC's current healthcare guidance is an N95 or higher respirator, gown, gloves and eye protection; a single-person room with the door closed when safe; an AIIR for aerosol-generating procedures when possible; and cohorting only with clients who have the same respiratory pathogen.
Two rules carry a lot of items. HIV and hepatitis B and C need only standard precautions: they spread through blood and needles, not the air. And localized shingles in a client with a normal immune system needs standard precautions with the lesions covered; only the disseminated or immunocompromised case goes to an AIIR. Contact, Droplet, Airborne: Pick the Right Door drills the sorting.
How long precautions last
Items also ask when precautions can stop. From CDC's isolation table and influenza guidance:
- Meningococcal disease: 24 hours after effective antibiotics start. Pertussis: 5 days after.
- Influenza: 7 days after onset, or until at least 24 hours after the fever resolves without fever-reducing medicine and respiratory symptoms are improving, whichever is longer.
- Tuberculosis: on effective therapy, improving, and 3 consecutive negative acid-fast sputum smears collected on separate days.
- Measles: 4 days after the rash appears (the whole illness if the client is immunocompromised). Chickenpox and zoster: until the lesions are dry and crusted.
- COVID-19: for most clients with mild to moderate illness who are not immunocompromised, at least 10 days after symptoms began, plus fever and symptom criteria.
PPE donning and doffing order (CDC)
CDC's sequence, from its PPE poster, starting with clean hands.
Donning:
- Gown, neck to knees and arms to wrists, tied at the neck and waist.
- Mask or respirator, nose band shaped to the face. Fit-check an N95 every time.
- Goggles or face shield.
- Gloves, pulled over the gown cuffs.
Doffing (CDC example 1):
- Gloves, the most contaminated item.
- Goggles or face shield, by the headband or ear pieces.
- Gown, touching only the inside, rolled inside out.
- Mask or respirator, bottom ties first, never touching the front.
- Hand hygiene, immediately.
CDC's second example peels the gown and gloves off together, then eye protection, then the mask, then hand hygiene. In both, everything comes off before you leave the room except a respirator, which comes off after you leave and close the door. Clean your hands mid-sequence whenever they become contaminated. Short version: gloves on last and off first; mask on second and off last.
Room assignment and cohorting
- Each airborne client gets their own AIIR (only in an outbreak, at infection prevention's direction, are clients with the same airborne infection grouped). An AIIR means negative pressure, door closed, at least 6 air changes an hour (12 in new construction). Without an AIIR, a private room with the door closed reduces spread until transfer.
- Contact and droplet clients get a private room first. When rooms run out, cohort clients with the same pathogen: beds more than 3 feet apart, curtain drawn, fresh PPE and hand hygiene between the two.
- The last private room goes to the contact client with uncontained drainage or stool incontinence, or the droplet client with heavy coughing and sputum.
- Avoid rooming an infected client with someone immunocompromised or expected to stay a long time, or a contact client with someone who has an open wound.
- Transport only when necessary: droplet and airborne clients wear a surgical mask; a contact client's infected area is covered, as are chickenpox and draining TB lesions.
Neutropenic precautions: protecting the client
Neutropenic (protective) precautions run the other way: they keep organisms away from a client who cannot fight them, usually a chemotherapy client with an absolute neutrophil count below about 1,000 (policy sets the trigger; below 500 is severe).
- Private room; meticulous hand hygiene; staff and visitors with an infection stay out.
- No fresh or dried flowers and no potted plants.
- Meat and eggs cooked through, raw produce washed well; some units order a low-microbial diet.
- No rectal temperatures, suppositories or enemas.
- Fever is the emergency. CDC tells clients to call for 38 °C (100.4 °F) or higher for over an hour, or one reading of 38.3 °C (101 °F). On the exam, report any fever at once.
Clients after an allogeneic stem cell transplant go into CDC's Protective Environment: a positive-pressure room with HEPA-filtered air and at least 12 air changes an hour. It mirrors an AIIR: negative pressure keeps TB air in, positive pressure keeps hallway air out. Burns: The Parkland Formula and Neutropenic Fever covers neutropenic fever.
The traps the exam sets
- A surgical mask for TB or measles. Those need a fit-tested N95; the surgical mask goes on the client for transport.
- Hand sanitizer after a C. diff room. Soap and water. Gloves never replace hand hygiene.
- "The nurse is immune to measles, so no respirator." CDC says wear an N95 regardless. Immunity decides assignment: susceptible staff stay out of measles and chickenpox rooms when immune staff are available.
- A droplet mask "within 3 feet". CDC says put it on when you enter the room.
- Waiting for results. Precautions start on suspicion.
- Cohorting by precaution type instead of organism: clients with MRSA and with C. diff are both on contact precautions and still do not share.
A worked room-assignment item
The nurse has one airborne infection isolation room left and four admissions. Which client should be placed in it?
- A client with influenza A, a temperature of 38.9 °C (102 °F) and a frequent cough. Droplet precautions: a private room and a surgical mask. Not the AIIR.
- A client with meningococcal meningitis who started IV antibiotics 6 hours ago. Droplet until 24 hours of effective therapy. Not the AIIR.
- A client with a 3-week productive cough, night sweats, weight loss and a cavity on the chest x-ray; sputum smears pending. Suspected pulmonary TB: airborne precautions now. The AIIR.
- A client with a healthy immune system and shingles in one band across the chest, lesions covered. Localized zoster in a normal host: standard precautions. Not the AIIR.
Two facts decided it: the route (only TB is airborne here) and the word "pending", because precautions start on suspicion. Had the shingles client been on chemotherapy, that client would need an AIIR too. Isolation lists also come as select-all-that-apply items (how SATA is scored), and the infection control practice questions repeat these patterns.
✅ Test yourself: 4 questions
Four infection-control items. Name the route and the precaution before you read the options. Every client is fictional; exam practice only, not medical advice.
Question 1 of 4
A nurse is teaching an assistive personnel (AP) how to clean the bedside commode of a client with Clostridioides difficile diarrhea. Which product should the AP use?
- A standard quaternary ammonium cleaning wipe
- Warm water and a mild liquid dish soap
- A bleach-based sporicidal disinfectant
- An alcohol-based surface disinfectant wipe
Show the answer and rationale
Answer: C
C. difficile forms spores that survive alcohol and many routine hospital disinfectants, so equipment and surfaces are cleaned with a sporicidal product such as a bleach-based disinfectant registered for C. difficile. Alcohol wipes and standard quaternary ammonium wipes do not reliably kill spores, and soap and water, which physically removes spores from the hands, does not disinfect equipment.
Question 2 of 4
During a surgical procedure, the circulating nurse observes the scrubbed surgical technologist. Which action by the technologist requires the circulating nurse to intervene?
- Folds the arms with the gloved hands tucked into the armpits
- Keeps the gloved hands clasped in front and above the waist
- Passes another scrubbed team member back to back
- Stands facing the sterile field while waiting for the surgeon
Show the answer and rationale
Answer: A
Only the front of a sterile gown from the chest to the level of the sterile field and the sleeves from 2 inches above the elbows to the cuffs are considered sterile, so gloved hands tucked under the arms are contaminated and the gloves must be changed. Keeping the hands together in front above the waist, passing other scrubbed members back to back and facing the sterile field all maintain sterility.
📚 Learn it: Clean Versus Sterile, and the Chain You Are Breaking
Question 3 of 4
A client in a crowded clinic waiting room has a fever and is coughing and sneezing often. Which action should the nurse take first?
- Give the client a surgical mask and seat the client away from others
- Have the client put on an N95 respirator until the visit is finished
- Ask the client to wait outside the building until a room is ready
- Give the client gloves to wear so that germs are not spread by hand
Show the answer and rationale
Answer: A
Respiratory hygiene and cough etiquette call for a surgical mask on the coughing client and separation from others in the waiting area, along with tissues and hand hygiene supplies. An N95 respirator is fit-tested equipment for staff, and a surgical mask is the standard source control for a coughing client; sending a sick client outside is not a substitute for masking and separation, and gloves do not stop respiratory droplets.
Question 4 of 4
A nurse is opening a kit wrapped in a sterile drape on the overbed table before inserting an indwelling urinary catheter. Which action is correct?
- Open the flap closest to the body first, then the two side flaps
- Hold the kit below waist level to keep it steady while opening
- Grasp the inner surface of each flap to pull it open evenly
- Open the first flap away from the body, reaching around it
Show the answer and rationale
Answer: D
The first flap of a wrapped sterile package is opened away from the nurse, reaching around rather than over the kit, then the side flaps and finally the flap nearest the nurse, so the nurse never reaches across the exposed sterile contents. Opening the near flap first means reaching over the field later, anything held below the waist is considered contaminated, and only the outer surface of the wrapper may be touched.
📚 Learn it: Clean Versus Sterile, and the Chain You Are Breaking
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❓ Frequently asked
Which diseases need airborne precautions?
Pulmonary or laryngeal tuberculosis (confirmed or suspected), measles, chickenpox and disseminated zoster, plus localized zoster in an immunocompromised client until dissemination is ruled out; chickenpox and zoster add contact precautions. All need a fit-tested N95 and a negative-pressure room.
What is the CDC order for donning and doffing PPE?
On: gown, mask or respirator, goggles or face shield, gloves. Off, in CDC's first example: gloves, goggles or face shield, gown, mask or respirator, then hand hygiene. A respirator comes off outside the room after the door is closed.
Is COVID-19 droplet or airborne precautions?
Neither exactly. CDC's current guidance is an N95 or higher respirator, gown, gloves and eye protection, a single-person room with the door closed, and an airborne infection isolation room for aerosol-generating procedures when possible.
Can two clients on isolation share a room?
Only if they have the same organism and are otherwise suitable roommates, which is called cohorting. Airborne clients each get their own AIIR outside an outbreak, and an infected client should not room with someone who is immunocompromised.
What are neutropenic precautions?
Measures that protect a client with a very low neutrophil count: a private room, strict hand hygiene, no sick visitors or staff, no flowers or plants, well-cooked food, no rectal temperatures or suppositories, and immediate reporting of any fever.
📝 Practice this topic
📚 Learn it in the app's lessons
Sources
- CDC, Transmission-Based Precautions (contact, droplet and airborne: placement, PPE, transport; reviewed April 2024)
- CDC, Guideline for Isolation Precautions, Appendix A: Type and Duration of Precautions Recommended for Selected Infections and Conditions
- CDC, Guideline for Isolation Precautions, IV: Recommendations (cohorting, more than 3 feet between beds, AIIR air changes, Protective Environment; reviewed Nov. 2023)
- CDC, Sequence for Putting On and Removing Personal Protective Equipment (poster, both removal examples)
- CDC, Infection Control Guidance: SARS-CoV-2 (N95, gown, gloves, eye protection; single-person room; AIIR for aerosol-generating procedures)
- CDC, Interim Guidance for the Use of Masks to Control Seasonal Influenza Virus Transmission (Droplet Precautions and how long they last; Jan. 2026)
- CDC, Interim Infection Prevention and Control Recommendations for Measles in Healthcare Settings (N95 for all staff regardless of immunity; updated Aug. 2025)
- CDC, Isolation Precautions Appendix A, Table 5: Components of a Protective Environment (positive pressure, HEPA, 12 air changes, no flowers or plants)
- CDC, Varicella-Zoster Virus: infection control for healthcare personnel (contagious until all lesions have crusted)
- CDC, Neutropenia and Risk for Infection (patient fact sheet: fever thresholds, food and hygiene precautions)
- OpenStax, Fundamentals of Nursing, 10.2 Asepsis and PPE (donning order, N95, soap and water for C. diff)
Accessed October 2026. Yearly figures name their year; NCSBN publishes a new statistics brief each June and a new test plan every three years (next: April 2029). Exam preparation only, never medical advice. NCLEX® is a registered trademark of NCSBN, which does not endorse this site.
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