🌀 20 questions · answers and rationales · free
NCLEX psychiatric medication and withdrawal practice questions
20 free NCLEX-style questions on lithium, SSRIs, MAOIs and the emergencies they cause, plus alcohol and benzodiazepine withdrawal and which withdrawal can kill, each with the answer and rationale.
Tap an answer to check it, or open "Show the answer and rationale" under each question. Every client is fictional. For exam practice only, not medical advice.
Question 1 of 20
A client who takes sertraline 100 mg daily for depression is admitted with a methicillin-resistant Staphylococcus aureus (MRSA) skin infection. The provider prescribes IV linezolid, and the first dose is due now. Which action should the nurse take?
- Give the linezolid and watch closely for agitation, tremor and fever
- Call the provider about the sertraline before giving the linezolid
- Give the linezolid and hold the sertraline until the provider rounds
- Give the linezolid and teach the client to avoid aged cheese and cured meats
Show the answer and rationale
Answer: B
Linezolid is an antibiotic that also inhibits monoamine oxidase, and the FDA has warned that giving it with serotonergic psychiatric drugs such as sertraline has caused serotonin syndrome, so the nurse contacts the provider before the first dose; another antibiotic is often chosen, and if linezolid is essential, the provider stops the SSRI and orders close monitoring. Giving the dose and watching for symptoms is the runner-up, but it accepts a preventable risk without the prescriber's decision. Holding the sertraline changes therapy without an order, and tyramine teaching is true for linezolid but does not address this interaction.
📚 Learn it: Lithium, SSRIs, MAOIs and the Emergencies They Cause
Question 2 of 20
A client at 12 weeks' gestation who has used heroin daily for 2 years tells the prenatal clinic nurse, 'I want to get off everything, even methadone or buprenorphine, so my baby isn't born addicted.' Which response by the nurse is best?
- 'Stopping now, early in the pregnancy, is safest, and we can arrange a supervised withdrawal for you.'
- 'Treatment with buprenorphine or methadone is safer for you and the baby than stopping opioids.'
- 'Cutting down slowly on your own over the next month will protect the baby from withdrawal.'
- 'Methadone is safe during pregnancy, but buprenorphine has to wait until after delivery.'
Show the answer and rationale
Answer: B
Methadone and buprenorphine are first-line treatment for opioid use disorder in pregnancy, and current recommendations favor them over supervised withdrawal because they lead to better outcomes and lower the risk of relapse. Supervised withdrawal is the runner-up because it sounds like the cleanest path, but quickly stopping opioids during pregnancy is not recommended. Cutting down alone carries the same relapse risk without support, and buprenorphine is as acceptable as methadone. Withdrawal in the newborn can follow treatment, but it is expected and treatable and is not a reason to avoid it.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
Question 3 of 20
A 66-year-old client who has taken lithium for 12 years, with steady levels, is seen in the clinic. The provider is adding four medications today. Which new prescription should the nurse clarify with the provider before the client leaves?
- Levothyroxine by mouth daily for an elevated TSH level
- Hydrochlorothiazide by mouth daily for hypertension
- Acetaminophen by mouth every 6 hours as needed for knee pain
- Propranolol by mouth twice daily for a fine hand tremor
Show the answer and rationale
Answer: B
Thiazide diuretics such as hydrochlorothiazide cause sodium loss, and the kidneys then hold on to lithium, which can push a steady level into the toxic range; the provider may choose another antihypertensive or adjust the lithium with close level checks. Propranolol is the runner-up because a beta blocker looks like an odd addition, but a low dose is a standard treatment for the fine tremor many clients have on lithium. Lithium can cause hypothyroidism, so levothyroxine for a high TSH treats an expected effect, and acetaminophen is a safer analgesic than an NSAID for a client on lithium.
📚 Learn it: Lithium, SSRIs, MAOIs and the Emergencies They Cause
Question 4 of 20
A nurse is teaching the roommate of a client with opioid use disorder how to use the naloxone nasal spray the client received at discharge. Which statement by the roommate indicates understanding?
- 'I'll spray one dose, wait 10 minutes to be sure it was opioids, and then decide about calling 911.'
- 'I'll give one dose and watch him for 30 minutes before repeating it, even if he stays unresponsive.'
- 'Once he wakes up, I'll watch him for an hour, and if he stays awake he won't need an ambulance.'
- 'I'll call 911, and if he isn't awake in 2 to 3 minutes, I'll give another dose.'
Show the answer and rationale
Answer: D
Naloxone teaching is: spray one dose, call 911 right away, and repeat a dose with a new device every 2 to 3 minutes until the person wakes up, then stay until help arrives. The runner-up is watching for an hour after he wakes up: it sounds cautious, but naloxone can wear off before the opioid does, especially with fentanyl or other long-acting opioids, so a person who wakes up can slip back into overdose and still needs emergency care. Waiting 10 minutes for certainty before calling delays help, and waiting 30 minutes between doses leaves an unresponsive person without reversal far too long; naloxone does not harm someone who has not taken opioids, so it is given whenever overdose is suspected.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
Question 5 of 20
A client who takes tranylcypromine for depression calls the clinic at 2100. About an hour after eating aged cheese and drinking draft beer at a party, the client developed a sudden, pounding headache at the back of the head, a stiff neck, palpitations and sweating. Which instruction should the nurse give?
- Call 911 or have someone drive you to the emergency department now
- Check your blood pressure now and call back if the top number is over 180
- Take acetaminophen and lie down in a dark, quiet room until it passes
- Drink several large glasses of water to help flush out the tyramine
Show the answer and rationale
Answer: A
A sudden occipital headache, stiff neck, palpitations and sweating after tyramine-rich foods such as aged cheese and draft beer in a client taking an MAOI signal a hypertensive crisis, which can cause a stroke, so the client needs emergency care now and should not drive. Checking the blood pressure first is the runner-up, since assessment usually comes first, but these symptoms already define the emergency, and waiting for a reading and a callback delays treatment. Acetaminophen and rest treat only the headache, and drinking water does not remove tyramine or lower the pressure.
📚 Learn it: Lithium, SSRIs, MAOIs and the Emergencies They Cause
Question 6 of 20 · Select all that apply
A 46-year-old client who drinks about 15 cans of beer a day is admitted to a medical unit with cellulitis of the leg; the last drink was 2 hours before arrival. The nurse reviews the admission data to plan care. Which findings increase the client's risk of severe or complicated alcohol withdrawal? Select all that apply.
- Had a withdrawal seizure the last time the client stopped drinking
- Has no tremor, sweating or anxiety on arrival
- Drinks beer rather than liquor
- Blood alcohol level of 240 mg/dL on arrival while awake and talking
- Has had at least one drink every day for the past month
- Takes alprazolam bought from a friend on most days
Show the answer and rationale
Answer: A, D, E, F
A past withdrawal seizure or delirium is the strongest predictor of another complicated withdrawal, and screening tools such as the PAWSS also count a blood alcohol level above 200 mg/dL at presentation, which shows high tolerance, recent regular use of benzodiazepines or other sedatives, and no alcohol-free days in the past month. The type of drink does not matter; the amount of alcohol does, and 15 beers a day is heavy use. Having no tremor or sweating 2 hours after the last drink is expected, because alcohol is still in the blood, and it does not predict a mild course.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
Question 7 of 20
A client who took lorazepam 1 mg three times daily for 6 years is in the third month of a planned taper with the prescriber, with small dose reductions every few weeks. Five days after the latest reduction, the client calls and reports more anxiety, poor sleep and irritability but no tremor, confusion, hallucinations or seizures. Which response by the nurse is best?
- 'You are in withdrawal, so you need to go to the emergency department right away.'
- 'Take an extra tablet on the hard nights, and then go back to the taper when you feel better.'
- 'Withdrawal from lorazepam isn't dangerous, so you can safely push through this on your own.'
- 'These symptoms are common after a cut. I'll tell your prescriber, who can slow the taper.'
Show the answer and rationale
Answer: D
Rebound anxiety, insomnia and irritability are common after a benzodiazepine dose reduction, and current tapering guidance sets the pace by what the client can tolerate, starting at about 5% to 10% every 2 to 4 weeks and often taking months or longer, so the nurse reports the symptoms and the prescriber can slow or delay the next cut. The emergency department is the runner-up, because benzodiazepine withdrawal can be life-threatening, but without tremor, confusion, hallucinations or seizures this is mild withdrawal. Extra doses taken on the client's own undo the plan, and calling the withdrawal harmless is false.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
Question 8 of 20
A 27-year-old client with schizophrenia started clozapine 3 weeks ago, and the dose reached 200 mg daily this week. Today the client says, 'I feel like I have the flu,' and reports mild chest pressure and shortness of breath when walking to the dayroom. Findings: temperature 100.6°F (38.1°C), resting heart rate 124 beats/min (88 beats/min before clozapine), BP 108/68 mm Hg, RR 22 breaths/min, SpO2 95% on room air. Yesterday's absolute neutrophil count (ANC) was 3,900/µL. Which action should the nurse take first?
- Hold the next clozapine dose and report the findings to the provider now
- Give the as-needed acetaminophen and recheck the temperature in 1 hour
- Draw a repeat ANC, because fever is often the first sign of neutropenia
- Teach the client to rise slowly, since a fast pulse is common with clozapine
Show the answer and rationale
Answer: A
Flu-like symptoms, chest pressure, dyspnea and a resting heart rate of 124 in the first 2 months of clozapine, when myocarditis most often appears, call for stopping the drug and a cardiac evaluation, so the nurse holds the dose and reports now. Acetaminophen is the runner-up, since a low-grade fever can be a harmless early drug effect, but it treats the number and ignores the chest symptoms. A normal ANC yesterday makes neutropenia unlikely, and tachycardia is common with clozapine, but not at rest with chest pressure and dyspnea.
📚 Learn it: Lithium, SSRIs, MAOIs and the Emergencies They Cause
Question 9 of 20
A client with Korsakoff syndrome from long-term heavy alcohol use tells the nurse a detailed story about playing golf with friends yesterday. The client has been on the unit all week. How should the nurse interpret this behavior?
- The client is showing the acute confusion of Wernicke encephalopathy
- The client is using denial to cope with being in the hospital
- The client is filling gaps in memory with invented details
- The client is lying to avoid talking about drinking
Show the answer and rationale
Answer: C
Confabulation, filling gaps in memory with invented but believable details, is a hallmark of Korsakoff syndrome, the chronic amnestic disorder that can follow thiamine deficiency in heavy alcohol use, and the client is not aware that the story is untrue. Wernicke encephalopathy, the acute form of the same deficiency, is the strongest distractor, but it typically shows as confusion with an unsteady gait and abnormal eye movements, not a calm, detailed story. The story is not deliberate lying or a defense mechanism such as denial, so confronting the client only causes distress; the nurse gently reorients the client and keeps a consistent routine.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
Question 10 of 20
A client who has taken fluoxetine 40 mg daily for 2 years without improvement is going to switch to phenelzine. The provider tells the client to take the last fluoxetine dose today. Which statement by the client indicates understanding of the plan?
- 'I'll start the phenelzine in 2 weeks, once the fluoxetine has cleared.'
- 'I won't start the phenelzine until at least 5 weeks after my last fluoxetine.'
- 'I can start the phenelzine tomorrow if I begin with the lowest dose.'
- 'I'll take both for the first week so my mood doesn't drop during the switch.'
Show the answer and rationale
Answer: B
Fluoxetine and its active metabolite norfluoxetine leave the body very slowly, so the labeling requires at least 5 weeks between the last fluoxetine dose and the first dose of an MAOI such as phenelzine to prevent serotonin syndrome. Two weeks is the runner-up because 14 days is the washout for other switches, such as starting fluoxetine after stopping an MAOI, but it is too short in this direction. Taking both for a week, or starting tomorrow at a low dose, combines an MAOI with a serotonergic drug, the interaction that causes serotonin syndrome whatever the dose.
📚 Learn it: Lithium, SSRIs, MAOIs and the Emergencies They Cause
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Question 11 of 20
A nurse is caring for four clients who drink large amounts of alcohol daily. Which client should the nurse monitor most closely for an alcohol withdrawal seizure at this time?
- A client whose last drink was 24 hours ago who has a hand tremor
- A client whose last drink was 2 hours ago who is slurring words and unsteady
- A client whose last drink was 72 hours ago who feels anxious
- A client whose last drink was 6 days ago who sleeps poorly
Show the answer and rationale
Answer: A
Alcohol withdrawal seizures typically occur within 6 to 48 hours of the last drink, most often around 24 hours, so the client at 24 hours with a tremor is in the window of greatest risk. The client at 72 hours is the strongest distractor, but that is the window for delirium tremens, which usually begins 2 to 4 days after the last drink, not the peak time for seizures. The client who drank 2 hours ago still has alcohol in the bloodstream and has not begun withdrawal, and poor sleep at 6 days is a lingering symptom well past the seizure window.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
Question 12 of 20
A 58-year-old client with diabetic gastroparesis has received IV metoclopramide every 6 hours for 4 days and has been drinking little. Today the client is confused and drenched in sweat, with rigid arms and legs. Temperature 103.1°F (39.5°C), HR 126 beats/min, BP 168/98 mm Hg and an hour later 102/60 mm Hg, RR 24 breaths/min. Creatine kinase is 9,600 units/L. Which action should the nurse take first?
- Give the as-needed acetaminophen and recheck the temperature in 1 hour
- Obtain blood cultures and start the sepsis protocol
- Give the as-needed diphenhydramine, since metoclopramide can cause muscle stiffness
- Hold the metoclopramide and notify the provider of the findings
Show the answer and rationale
Answer: D
Metoclopramide blocks dopamine as antipsychotics do, and high fever, generalized rigidity, confusion, swings in blood pressure and a very high creatine kinase in a dehydrated client taking it point to neuroleptic malignant syndrome; stopping the dopamine blocker comes first, then the provider directs cooling, IV fluids and possibly dantrolene or bromocriptine. Sepsis is the runner-up because fever, tachycardia and confusion fit it, but sepsis does not explain the rigidity and the creatine kinase, and cultures leave the cause running. Diphenhydramine treats acute dystonia, not this syndrome, and waiting an hour delays the essential step.
📚 Learn it: Lithium, SSRIs, MAOIs and the Emergencies They Cause
Question 13 of 20
A client admitted 2 days after stopping heavy methamphetamine use has slept most of both days and eats large meals. He tells the nurse, 'I'm worthless. Nothing is ever going to get better.' Which action should the nurse take first?
- Encourage the client to join a unit group to talk about his feelings
- Reassure the client that this low mood is expected and usually passes
- Ask the client directly whether he is having thoughts of suicide
- Ask how his sleep and appetite have changed since admission
Show the answer and rationale
Answer: C
The crash after heavy stimulant use brings fatigue, hypersomnia, increased appetite, and a dysphoric mood that can include suicidal thinking, so statements of worthlessness and hopelessness call for direct assessment of suicidal thoughts first. The runner-up, encouraging the client to talk about his feelings in a group, is supportive and may help later, but it is not a safety assessment and cannot come before ruling out suicidal intent. Asking about sleep and appetite reviews expected crash symptoms rather than the risk in his words, and reassuring him that the low mood usually passes dismisses that risk without assessing it.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
Question 14 of 20 · Select all that apply
A client with opioid use disorder is being discharged after 7 days of medically supervised withdrawal from fentanyl and has declined buprenorphine for now. The nurse teaches the client's parents how to prevent a fatal overdose. Which statements should the nurse include? Select all that apply.
- 'You can buy naloxone nasal spray at a pharmacy without a prescription.'
- 'After a week without opioids, an amount he used to take could now stop his breathing.'
- 'Naloxone will also reverse an overdose of alcohol or sleeping pills.'
- 'If he is snoring loudly and you can't wake him, let him sleep it off.'
- 'If he starts breathing after the naloxone, roll him onto his side while you wait for help.'
- 'Putting him in a cold shower or an ice bath can help wake him up.'
Show the answer and rationale
Answer: A, B, E
Tolerance falls quickly after withdrawal, so a return to his old amount, especially of fentanyl, can be fatal, which makes the weeks after detoxification a time of high overdose risk. Naloxone nasal spray is sold without a prescription, and a person who begins breathing is turned onto the side so the airway stays open if he vomits while help is on the way. Cold showers and ice baths waste time and can cause harm, and loud snoring or gurgling in someone who cannot be woken is a sign of overdose, not sleep. Naloxone reverses only opioids, though it is still given whenever opioids might be involved.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
Question 15 of 20
A client with severe depression returns to the unit 2 hours after a first electroconvulsive therapy treatment and asks the nurse, 'Why can't I remember eating breakfast or going downstairs?' Which response by the nurse is best?
- 'Not remembering events close to a treatment is common and expected; memory generally improves after the series ends.'
- 'The anesthetic and muscle relaxant given before the treatment cloud your memory of the time just before and after it.'
- 'Some memory loss shows the treatment reached the brain, and it usually builds a little more with each treatment in the series.'
- 'Memory gaps like that can happen after a first treatment, but I'll notify the provider to consider imaging of your head.'
Show the answer and rationale
Answer: A
Transient confusion and loss of memory for events around the treatment are the most common adverse effects of electroconvulsive therapy; confusion usually clears within a few hours, and memory generally improves over weeks to months after the course ends, although memories from right around a treatment may never fully return. The runner-up blames the anesthetic and muscle relaxant: those drugs are brief and given for comfort and safety during the induced seizure, and they do not explain the gap; the memory loss is an effect of the treatment itself. Memory loss is a side effect, not a sign the treatment is working, though cumulative problems over a course are watched for and reported. Imaging is not indicated for an expected effect; the nurse would report a headache unrelieved by analgesics, prolonged disorientation, or any new neurologic deficit.
📚 Learn it: Lithium, SSRIs, MAOIs and the Emergencies They Cause
Question 16 of 20
A client who took paroxetine 40 mg daily for 3 years stopped it on her own 3 days ago because she 'felt better.' She calls the clinic reporting dizziness, nausea, irritability, vivid dreams and brief 'electric zaps' in her head when she moves her eyes. She denies thoughts of self-harm, and her temperature is normal. Which response by the nurse is best?
- 'Go to the emergency department right now, because these are the signs of serotonin syndrome.'
- 'These symptoms are harmless and fade within days, so you can simply wait them out.'
- 'This can follow stopping suddenly. I'll ask your prescriber about restarting and tapering.'
- 'These symptoms after stopping mean that your depression has come back and needs a higher dose.'
Show the answer and rationale
Answer: C
Dizziness, nausea, irritability, vivid dreams and electric-shock sensations days after abruptly stopping paroxetine are antidepressant discontinuation symptoms; when they are troublesome, the usual approach is to resume the previous dose and then taper more gradually, and the prescriber needs to know she stopped a drug that protects against relapse. Waiting it out is the runner-up, because the symptoms are not dangerous and often ease, but it leaves her uncomfortable and without a plan. Symptoms beginning within days of stopping fit discontinuation rather than relapse, and serotonin syndrome comes from too much serotonin, not from stopping an SSRI.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
Question 17 of 20
A nurse is reviewing the history of a client who has a new prescription for bupropion for depression. Which finding should the nurse report to the provider before the first dose?
- Smokes a pack of cigarettes a day and wants to quit
- Has a blood pressure of 134/86 mm Hg today
- Had sexual side effects while taking sertraline
- Has bulimia nervosa with daily binging and purging
Show the answer and rationale
Answer: D
Bupropion lowers the seizure threshold, and it is contraindicated in clients with a current or past diagnosis of bulimia or anorexia nervosa because these clients had a higher rate of seizures, so this finding must be reported. Bupropion can raise blood pressure, so a reading of 134/86 mm Hg is recorded and rechecked during therapy, but it does not stop the first dose. Smoking cessation is another approved use of bupropion, and its low rate of sexual side effects is often why it is chosen after an SSRI.
📚 Learn it: Lithium, SSRIs, MAOIs and the Emergencies They Cause
Question 18 of 20
A client in alcohol withdrawal has a symptom-triggered protocol: give lorazepam for a CIWA-Ar score of 10 or higher and reassess 1 hour after each dose. The score was 6 at 0800. At 1000 the client has a moderate tremor, sweating, anxiety, and nausea, with a score of 16 and a heart rate of 112 beats/min. Which action should the nurse take?
- Give the prescribed lorazepam and reassess the score in 1 hour
- Hold the lorazepam and notify the provider of the heart rate first
- Give the lorazepam now and repeat it in 1 hour without rescoring
- Give the lorazepam and reassess the score in 2 hours
Show the answer and rationale
Answer: A
In symptom-triggered therapy the benzodiazepine is given whenever the CIWA-Ar score reaches the protocol threshold, here 10 or higher, and the score is rechecked 1 hour after the dose. The runner-up gives the right drug at the right threshold but stretches reassessment to 2 hours, which can miss a poor response while withdrawal progresses toward seizures and delirium. Holding the dose to report the heart rate sounds careful, but tachycardia is an expected withdrawal sign that the lorazepam itself treats, and repeating the dose in 1 hour without rescoring removes the symptom check that drives the protocol.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
Question 19 of 20
A 20-year-old college student tells the nurse, 'I only drink on weekends, but at parties I usually have five or six drinks in a couple of hours.' Which response by the nurse is most appropriate?
- 'That pattern is binge drinking, which raises your risk of injury. Can we talk about it?'
- 'That pattern suggests an alcohol use disorder, so I'll refer you for treatment.'
- 'Alternating each drink with a glass of water will help you pace yourself.'
- 'Limiting your drinking to weekends keeps your overall risk fairly low.'
Show the answer and rationale
Answer: A
Binge drinking is a pattern that brings the blood alcohol level to 0.08%, typically 4 or more drinks for women or 5 or more for men within about 2 hours, and it raises the risk of injuries, assault, alcohol poisoning and unplanned sex, so the nurse names the pattern without judgment and offers a brief intervention, as recommended for unhealthy alcohol use in adults. Referral for treatment takes the drinking seriously, but one heavy-drinking pattern does not by itself establish an alcohol use disorder. Alternating with water is a useful tip but skips the conversation about the amount, and weekend-only drinking can still be high risk.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
Question 20 of 20
A client with alcohol use disorder on a medical unit is found sweaty and confused and cannot follow directions. The fingerstick glucose is 41 mg/dL, and a saline lock is in place. Prescriptions include IV dextrose 50% per the hypoglycemia protocol for a glucose below 70 mg/dL in a client who cannot swallow safely, and IV thiamine daily; the first thiamine dose is expected from the pharmacy in 30 minutes. Which action should the nurse take?
- Give orange juice by mouth and recheck the glucose in 15 minutes
- Give the dextrose now and the thiamine as soon as it is available
- Send a venous glucose sample to the laboratory before treating
- Wait for the thiamine, then give it just before the dextrose
Show the answer and rationale
Answer: B
Severe hypoglycemia with confusion is an emergency that can injure the brain, so the IV dextrose is given now and the thiamine as soon as it can be given. Thiamine first is the runner-up because it is the usual rule in heavy drinkers, since a glucose load can tip a thiamine-deficient brain into Wernicke encephalopathy, but that rule guides planned dextrose infusions and should not delay treatment of hypoglycemia. Juice by mouth risks aspiration in a client who cannot follow directions, and waiting for a laboratory value delays treatment of a reading that matches the symptoms.
📚 Learn it: Which Withdrawal Can Kill: Alcohol, Benzos, and the Ones That Just Hurt
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